Search results for "Recent onset"

Treatment of Recent-Onset Type 1 Diabetic Patients With DiaPep277: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial.

2014

OBJECTIVE To evaluate safety and efficacy of DiaPep277 in preserving β-cell function in type 1 diabetic patients. RESEARCH DESIGN AND METHODS DIA-AID 1 is a multinational, phase 3, balanced-randomized, double-blind, placebo-controlled, parallel-group clinical study. Newly diagnosed patients (N = 457, aged 16–45 years) were randomized to subcutaneous injections of DiaPep277 or placebo quarterly for 2 years. The primary efficacy end point was the change from baseline in the area under the glucagon-stimulated C-peptide curve. Secondary end points were the change from baseline in mixed-meal stimulated C-peptide secretion and in fasting C-peptide and achieving target HbA1c ≤7% (≤53 mmol/mol). P…

Usefulness of routine hepatitis C virus, hepatitis B virus, and parvovirus B19 serology in the diagnosis of recent-onset inflammatory arthritides.

2005

The role of US examination in the management of acute abdomen.

2013

Acute abdomen is a medical emergency, in which there is sudden and severe pain in abdomen of recent onset with accompanying signs and symptoms that focus on an abdominal involvement. It can represent a wide spectrum of conditions, ranging from a benign and self-limiting disease to a surgical emergency. Nevertheless, only one quarter of patients who have previously been classified with an acute abdomen actually receive surgical treatment, so the clinical dilemma is if the patients need surgical treatment or not and, furthermore, in which cases the surgical option needs to be urgently adopted. Due to this reason a thorough and logical approach to the diagnosis of abdominal pain is necessary. …

Arterial Stiffness in Periodontal Disease

2007

A physically demanding occupation predicts premature retirement among patients with erosive arthritis

1998

The aim of this study was to assess the intensity of exercise and energy expenditure of patients with recent onset inflammatory arthritis in their occupational environments and leisure time physical activities. The exercise intensities and energy expenditures of 41 early inflammatory arthritis patients and 20 matched healthy controls were assessed in occupational work and in leisure time physical activities during a 3.5-year follow-up using metabolic unit values. Disease activity was assessed by erythrocyte sedimentation rate and Ritchie's articular index. Subjective disability was assessed by the Stanford Health Assessment Questionnaire and the extent of joint damage on X-rays of the hands…